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San Francisco 49ers quarterback Brock Purdy and wide receiver Ricky Pearsall have been ruled out for the team’s game against the Tampa Bay Buccaneers on Sunday.
Purdy is out with a toe injury, while Pearsall is out with a knee injury.
Backup quarterback Mac Jones, who is listed as questionable on the injury report, is expected to start for the 49ers. Jones injured his oblique on his final play of last week’s overtime win over the Los Angeles Rams and was limited all week in practice, but should be ready to play, according to head coach Kyle Shanahan.
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San Francisco 49ers quarterback Brock Purdy (13) after the game against the Jacksonville Jaguars at Levi’s Stadium in Santa Clara, California, on September 28, 2025. (Darren Yamashita/Image Images)
Purdy, 25, initially injured his toe in the season opener against the Seattle Seahawks. He missed the next two games and returned to play in Week 4 against the Jacksonville Jaguars, but reaggravated the injury and missed last week’s game against the Los Angeles Rams.
Purdy, who signed a five-year, $265 million extension in the offseason, will miss his sixth game due to injury in San Francisco’s final 13 games dating back to last season.
While the 49ers certainly miss Purdy, they haven’t missed a beat with Jones, as they are 3-0 in his starts.
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San Francisco 49ers wide receiver Ricky Pearsall (1) before the game against the Jacksonville Jaguars at Levi’s Stadium in Santa Clara, California, on September 28, 2025. (Darren Yamashita/Image Images)
The 27-year-old completed 66.7% of his passes for 905 yards with six touchdowns and one interception in three games.
Jones is one of only two quarterbacks, along with Matthew Stafford in 2021 with the Rams, to win his first three starts with a franchise while throwing for at least 900 yards and six touchdowns.
San Francisco 49ers quarterback Mac Jones reacts during the second half of an NFL football game against the Los Angeles Rams, Thursday, Oct. 2, 2025, in Inglewood, California. (Brian Rothmuller/Icon Sportswire via Getty Images)
However, for the second straight week, Jones won’t have Pearsall to throw to. Jauan Jennings, another of Jones’ top targets, is listed as questionable with ankle and rib injuries that kept him out of last week’s game.
The 49ers (4-1) play the Buccaneers (4-1) at 4:25 p.m. ET on Sunday.
