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Arizona Cardinals quarterback Kyler Murray has been ruled out for Sunday’s game against the Indianapolis Colts due to a foot injury.
Murray did not practice Wednesday or Thursday. He was limited in practice on Friday. And, about an hour before kickoff against the Colts, the team disabled it. Senior quarterback Jacoby Brissett will start in his place.
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Arizona Cardinals quarterback Kyler Murray (1) attempts to throw a pass during the first half of an NFL football game against the Tennessee Titans, Sunday, Oct. 5, 2025, in Glendale, Arizona. (AP Photo/Rick Scuteri)
The star quarterback suffered a midfoot sprain. NFL Network reported that Murray may have to sit out more than just the Week 6 game against Indianapolis. He missed two plays during the team’s calamitous loss to the Tennessee Titans last week.
Murray, who is in the seventh year of his career, has 962 passing yards and six touchdown passes for the Cardinals. He also has three interceptions on the year.
Arizona Cardinals quarterback Kyler Murray (1) runs the ball against Tennessee Titans safety Amani Hooker, right, during the second half of an NFL football game Sunday, Oct. 5, 2025 in Glendale, Arizona. (AP Photo/Ross D. Franklin)
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He was Arizona’s first overall pick during the 2019 draft. He was the 2019 Offensive Rookie of the Year and led the team to the playoffs during the 2021 season. He signed a five-year contract extension worth $230.5 million in 2022.
Arizona will enter the Week 6 game with a 2-3 record. The team ranks 23rd in points scored and 26th in yards gained. The Cardinals finished 8-9 last season.
Arizona Cardinals quarterback Kyler Murray (1) and wide receiver Marvin Harrison Jr. (18) leave the field after the team’s loss in an NFL football game against the Tennessee Titans, Sunday, Oct. 5, 2025, in Glendale, Arizona. (AP Photo/Ross D. Franklin)
Kedon Slovis is listed as the third quarterback on the Cardinals’ roster.
