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Christian McCaffrey and the San Francisco 49ers defense had a night.
The star running back had 201 yards from scrimmage and two touchdowns as San Francisco topped the Atlanta Falcons, 20-10, on Sunday night.
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San Francisco 49ers running back Christian McCaffrey (23) celebrates his touchdown against the Atlanta Falcons in the first half of an NFL football game, Sunday, Oct. 19, 2025, in Santa Clara, California. (AP Photo/Godofredo A. Vásquez)
McCaffrey ran for 129 yards and scored two touchdowns on the ground. He also had seven receptions for 72 yards. He started the scoring in the second quarter when he helped put San Francisco up 7-3. He then put the dagger in the hearts of Falcons fans when he was pulled and pushed into the end zone with 2:26 left in the game.
It was that kind of frustrating night for the Falcons.
Michael Penix Jr. was 21 of 38 for 241 yards and a touchdown. He was sacked twice and lost a fumble. But after two big wins against the Washington Commanders and Buffalo Bills, the Falcons’ offense was expected to have a little more firepower than they showed against a depleted 49ers defense.

San Francisco 49ers defensive end Mykel Williams (98) celebrates in the first half of an NFL football game against the Atlanta Falcons, Sunday, Oct. 19, 2025, in Santa Clara, California. (AP Photo/Kelley L. Cox)
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Atlanta ran nine drives on the night and could only muster 19 first downs. The team was 5 of 11 on third downs and 0 of 2 on fourth down conversion attempts.
San Francisco had 324 yards of total offense to Atlanta’s 292.
The 49ers were able to limit running back Bijan Robinson to 40 rushing yards on 14 carries. He had six receptions for 52 yards and a touchdown. San Francisco quarterback Mac Jones replaced Brock Purdy. He had 152 passing yards and one interception.

Atlanta Falcons running back Bijan Robinson (7) runs near San Francisco 49ers safety Ji’Ayir Brown (27) in the second half of an NFL football game, Sunday, Oct. 19, 2025, in Santa Clara, California. (AP Photo/Kelley L. Cox)
Despite the injuries that have plagued San Francisco since Week 1, the 49ers moved to 5-2 with the victory. Atlanta fell to 3-3.