
Prince Frederik of Luxembourg died on March 1, 2025, at the age of 22, his family said in a statement.
He was the youngest son of Prince Robert of Luxembourg and Princess Julie de Nassau.
His death was due to Polg mitochondrial disease, a rare genetic condition that he had fought since he was diagnosed 14 years old.
The news was announced by his family, with his father sharing a sincere tribute on the Polg Foundation website, a Frederik organization founded to support the research on the disease.

In a deeply moving statement, their parents said:
“It is with a very heavy heart that my wife and I would like to inform him about the death of our son, Frederik.”
“Last Friday, February 28, on the” Rare Disease Day “, our dear son called us to his room to talk to him for the last time. Frederik found strength and courage to say goodbye to each of us in turn: his brother, Alexander; his sister, Charlotte; to me; his three cousins, Charly, Louis and Donall; his brother -in -law, meek; Mark. All
“Frederik’s last question for me, before his other comments was:” Dad, are you proud of me? “He had barely been able to speak for several days, so the clarity of these words was as surprising as the weight of the moment was deep. The answer was very easy, and he had heard it, O many times … but at this time, he needed peace of mind that he had contributed everything that he could possibly in his brief and beautiful existence and that now he could finally move on.”