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With the 2026 NFL schedule now officially released, sportsbooks wasted no time posting opening lines for Week 1.
Headlined by a Super Bowl rematch on Wednesday night between the Seahawks and Patriots, as well as the first NFL game in Australia between the Rams and 49ers, opening week is absolutely loaded.
And while kickoff is still months away, it’s never too early to take a look at the Week 1 odds after the schedule is released.
Here are the lines for every Week 1 matchup on DraftKings Sportsbook as of May 15.
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WEDNESDAY, September 9
Patriots @ Seahawks
Spread: Seahawks -3.5
Money line: Seahawks -205, Patriots +170
Out/out: 44.5
THURSDAY, September 10
49ers @ Rams (Australia)
Spread: Rams -2.5
Money line: Rams -155, 49ers +130
Out/of: 48.5
SUNDAY, September 13
Saints @ Lions
Spread: Lions -7
Moneyline: Lions -325, Saints +260
Out/of: 48.5
Bears @ Panthers
Spread: Bears -2.5
Money line: Bears -135, Panthers +114
Out/out: 44.5
Ravens @ Colts
Spread: Crows -3.5
Moneyline: Ravens -185, Colts +154
Out/out: 49.5
Invoices @ Texans
Spread: Banknotes -1.5
Money line: bills -112, jeans -108
Out/of: 45.5
Falcons @ Steelers
Spread: Steelers -3
Money line: Steelers -175, Falcons +145
Out/out: 42.5
Buccaneers @ Bengals
Spread: Bengals -3.5
Money line: Bengals -198, Buccaneers +164
Out/out: 50.5
Browns @ Jaguars
Spread: Jaguars -7
Moneyline: Jaguars -285, Browns +230
Out/of: 40.5
Jets @ Titans
Spread: Titans -3
Moneyline: Titans -170, Jets +142
Out/out: 39.5
Commanders @ Águilas
Spread: Eagles -5.5
Money line: Eagles -238, Commanders +195
Out/out: 46.5
Packers @ Vikings
Spread: Packers -1.5
Moneyline: Packers -125, Vikings +105
Out/out: 44.5
Cardinals @ Chargers
Spread: Chargers -11.5
Moneyline: Chargers -625, Cardinals +455
Out/of: 45.5
Dolphins @ Raiders
Spread: Raiders -3
Moneyline: Raiders -180, Dolphins +150
Out/out: 41.5
Jeans @ Giants
Spread: Jeans -2.5
Moneyline: Cowboys -130, Giants +110
Out/of: 48.5
MONDAY September 14
Broncos @ Chiefs
Spread: Bosses -2.5
Moneyline: Chiefs -155, Broncos +130
Out/out: 42.5
